Telomerase Activity in Periampullary Tumors Correlates With Aggressive Malignancy
نویسندگان
چکیده
منابع مشابه
Telomerase Activity Associated with Acquisition of Malignancy
Shortening of telomeres may contribute to the control of the proliferative capacity of normal cells, and telomerase, the enzyme that elongates telomeric DNA, may be essential for unlimited cell proliferation. We have shown previously that telomerase activity is present in human cells im mortalized in vitro and in metastatic ovarian carcinoma cells but is undetectable in normal cultured cells or...
متن کاملTelomerase activity in gynecological tumors.
Telomerase is a ribonucleoprotein that synthesizes telomeric DNA onto chromosomal ends using an RNA component as a template. Extension of telomeric repeats by telomerase prevents telomere shortening with cell divisions and contributes to chromosomal stability, possibly leading to immortalization of the cells. In the present study, we determined the telomerase activity of gynecological tumors an...
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Purpose: Telomerase is considered a molecular marker for malignancy. The aim of this study was to determine telomer-ase activity (TA) as a prognostic factor at diagnosis and as a marker for minimal residual disease during therapy and follow up in nonmetastatic Ewing family of tumors (EFT). Patients and Methods: Primary tumor specimens and 97 peripheral blood (PBL) samples from 31 EFT patients w...
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BACKGROUND The activity of the ribonucleoprotein enzyme telomerase is not detected in normal somatic cells; thus, with each cell division, the ends of chromosomes consisting of the telomeric repeats TTAGGG progressively erode. The current model gaining support is that telomerase activity in germline and immortal cells maintains telomere length and thus compensates for the "end-replication probl...
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Telomerase, the enzyme that stabilizes telomere length is reactivated with almost all cancer types, and may be a useful diagnostic marker for malignancy. Telomerase activity has been detected in germ line cells and most cancer cells, whereas most normal somatic cells have no clearly detectable telomerase activity. In our study, we aim to detect telomerase activity in 20 human central nervous sy...
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ژورنال
عنوان ژورنال: Annals of Surgery
سال: 2001
ISSN: 0003-4932
DOI: 10.1097/00000658-200109000-00008